Mmadu EGFR Gene 29 mmadụ

Ọrịa cancer akpa ume abụrụla ihe kacha ebute ọnwụ kansa n'ụwa niile, na-eyi ahụike mmadụ egwu nke ukwuu.Ọrịa cancer akpa ume na-abụghị obere cell bụ ihe dị ka pasent 80 nke ndị ọrịa cancer akpa ume.EGFR bụ ugbu a ihe mgbaru ọsọ molekụla kachasị mkpa maka ọgwụgwọ ọrịa kansa akpa ume na-abụghị obere cell.phosphorylation nke EGFR nwere ike ịkwalite uto cell tumor, ọdịiche, mbuso agha, metastasis, mgbochi apoptosis, na ịkwalite angiogenesis tumor.EGFR tyrosine kinase inhibitors (TKI) nwere ike igbochi ụzọ akara EGFR site na igbochi EGFR autophosphorylation, si otú ahụ gbochie mmụba na ọdịiche nke mkpụrụ ndụ tumo, na-akwalite apoptosis cell tumor, ibelata angiogenesis tumor, wdg, iji nweta ọgwụgwọ ezubere iche maka tumor.Ọnụ ọgụgụ dị ukwuu nke ọmụmụ egosila na ọgwụgwọ ọgwụgwọ EGFR-TKI nwere njikọ chiri anya na ọnọdụ nke EGFR gene mutation, ma nwee ike igbochi uto mkpụrụ ndụ tumo na EGFR gene mutation.Mkpụrụ ndụ EGFR dị na obere ogwe aka nke chromosome 7 (7p12), nke nwere ogologo 200Kb zuru oke ma mejupụtara exons 28.Mpaghara mutated dị na exons 18 ruo 21, codons 746 ruo 753 ihichapụ ngbanwe na exon 19 bụ ihe dị ka 45% na ngbanwe L858R na exon 21 bụ ihe dịka 40% ruo 45%.Ntuziaka NCCN maka nchọpụta na ọgwụgwọ ọrịa cancer akpa ume na-abụghị obere cell na-ekwu n'ụzọ doro anya na a chọrọ nyocha mkpụrụ ndụ EGFR tupu nchịkwa EGFR-TKI.A na-eji ngwa ule a na-eduzi nchịkwa epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI), ma na-enye ihe ndabere maka ọgwụ ahaziri onwe ya maka ndị ọrịa nwere ọrịa cancer akpa ume na-abụghị obere cell.A na-eji ngwa a naanị maka nchọpụta mmụgharị nkịtị na mkpụrụ ndụ EGFR na ndị ọrịa nwere ọrịa kansa akpa ume na-abụghị obere cell.Nsonaazụ ule a bụ maka ntụaka ụlọọgwụ naanị na ekwesighi iji ya dịka naanị ihe ndabere maka ọgwụgwọ n'otu n'otu nke ndị ọrịa.Ndị dọkịta kwesịrị ịtụle ọnọdụ onye ọrịa, ihe ngosi ọgwụ, na ọgwụgwọ A na-eji mmeghachi omume na ihe ngosi nyocha ụlọ nyocha ndị ọzọ na ihe ndị ọzọ iji kpee nsonaazụ ule n'ụzọ zuru ezu.