Mmadụ CYP2C19 Gene Polymorphism

Nkọwa dị mkpirikpi:

A na-eji ngwa a maka nchọpụta qualitative in vitro nke polymorphism nke mkpụrụ ndụ ihe nketa CYP2C19 CYP2C19 * 2 (rs4244285, c.681G>A), CYP2C19 * 3 (rs4986893, c.636G>A), CYP2C19, 240.6 (c. > T) na DNA genomic nke ihe nlele ọbara mmadụ dum.


Nkọwa ngwaahịa

Mkpado ngwaahịa

Aha ngwaahịa

HWTS-GE012A-Ihe nchọta nke mmadụ CYP2C19 Gene Polymorphism (Fluorescence PCR)

Asambodo

CE

Epidemiology

CYP2C19 bụ otu n'ime ọgwụ na-eme ka enzymes metabolize dị mkpa na ezinụlọ CYP450.Ọtụtụ endogenous mkpụrụ na banyere 2% nke ụlọ ọgwụ ọgwụ na-metabolized site CYP2C19, dị ka metabolism nke antiplatelet aggregation inhibitors (dị ka clopidogrel), proton mgbapụta inhibitors (omeprazole), anticonvulsants, wdg CYP2C19 gene polymorphisms nwekwara ọdịiche na metabolizing ikike nke metabolizing ike. ọgwụ ndị metụtara ya.Mgbanwe ndị a nke * 2 (rs4244285) na * 3 (rs4986893) na-akpata mfu nke ọrụ enzyme nke mkpụrụ ndụ CYP2C19 kpuchiri ya na adịghị ike nke ike mkpụrụ ndụ metabolic, ma na-abawanye ntinye ọbara, ka o wee mee ka mmeghachi omume ọgwụ ọjọọ metụtara ya. itinye uche n'ọbara.* 17 (rs12248560) nwere ike ịbawanye ọrụ enzyme nke mkpụrụ ndụ CYP2C19 kpuchiri ya, mmepụta nke metabolites na-arụ ọrụ, ma welie mgbochi nchịkọta platelet na ịbawanye ohere ọbara ọgbụgba.N'ihi na ndị mmadụ na-eji nwayọọ metabolism nke ọgwụ ọjọọ, na-ewere nkịtị doses ruo ogologo oge ga-eme ka oké njọ na-egbu egbu na mmetụta: tumadi mmebi imeju, hematopoietic usoro mmebi, Central ụjọ usoro mmebi, wdg, nke nwere ike iduga ọnwụ na oké njọ.Dị ka onye dị iche iche nke kwekọrọ ekwekọ ọgwụ metabolism, ọ na-kewara n'ime anọ phenotypes, ya bụ ultra-fast metabolism (UM, * 17/*17, * 1/*17), ngwa ngwa metabolism (RM, * 1/*1). ) , Metabolism nke etiti (IM, *1/*2, *1/*3), ngwa ngwa metabolism (PM, *2/*2, *2/*3, *3/*3).

Ọwa

FAM CYP2C19*2
CY5 CYP2C9*3
ROX CYP2C19*17
VIC/HEX IC

Nka nka

Nchekwa Mmiri: ≤-18℃
Ndụ nchekwa Ọnwa iri na abụọ
Ụdị ụdị Ọbara anticoagulated EDTA ọhụrụ
CV ≤5.0%
LoD 1.0ng/μL
Nkọwapụta Enweghị mmeghari mmegharị na usoro ndị ọzọ na-agbanwe agbanwe (CYP2C9 gene) na genome mmadụ.Mgbanwe nke saịtị CYP2C19*23, CYP2C19*24 na CYP2C19*25 na-abụghị ebe a na-achọpụta ngwa a enweghị mmetụta na nchọta nke ngwa a.
Ngwa ndị ọdabara Ngwa Biosystem 7500 ezigbo oge PCR Sistemu

Ngwa Biosystem 7500 Ngwa PCR ngwa ngwa ozugbo

Sistemụ PCR Real-Time QuantStudio®5

Sistemụ PCR SLAN-96P ezigbo oge

Sistemụ PCR Real-Time LightCycler®480

Sistemụ nchọpụta PCR nke LineGene 9600 Plus

MA-6000 Real-Time Quantitative Thermal Cycler

BioRad CFX96 ezigbo oge PCR sistemụ

BioRad CFX Opus 96 PCR ezigbo oge

Usoro ọrụ

Reagent mmịpụta akwadoro:Macro & Micro-Test Viral DNA/RNA Kit (HWTS-3001, HWTS-3004-32, HWTS-3004-48, HWTS-3004-96) na Macro & Micro-Test Automatic Nucleic Acid Extractor (HWTS-3006).


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