Mmadụ CYP2C19 Gene Polymorphism

CYP2C19 bụ otu n'ime ọgwụ na-eme ka enzymes metabolize dị mkpa na ezinụlọ CYP450.Ọtụtụ endogenous mkpụrụ na banyere 2% nke ụlọ ọgwụ ọgwụ na-metabolized site CYP2C19, dị ka metabolism nke antiplatelet aggregation inhibitors (dị ka clopidogrel), proton mgbapụta inhibitors (omeprazole), anticonvulsants, wdg CYP2C19 gene polymorphisms nwekwara ọdịiche na metabolizing ikike nke metabolizing ike. ọgwụ ndị metụtara ya.Mgbanwe ndị a nke * 2 (rs4244285) na * 3 (rs4986893) na-akpata mfu nke ọrụ enzyme nke mkpụrụ ndụ CYP2C19 kpuchiri ya na adịghị ike nke ike mkpụrụ ndụ metabolic, ma na-abawanye ntinye ọbara, ka o wee mee ka mmeghachi omume ọgwụ ọjọọ metụtara ya. itinye uche n'ọbara.* 17 (rs12248560) nwere ike ịbawanye ọrụ enzyme nke mkpụrụ ndụ CYP2C19 kpuchiri ya, mmepụta nke metabolites na-arụ ọrụ, ma welie mgbochi nchịkọta platelet na ịbawanye ohere ọbara ọgbụgba.N'ihi na ndị mmadụ na-eji nwayọọ metabolism nke ọgwụ ọjọọ, na-ewere nkịtị doses ruo ogologo oge ga-eme ka oké njọ na-egbu egbu na mmetụta: tumadi mmebi imeju, hematopoietic usoro mmebi, Central ụjọ usoro mmebi, wdg, nke nwere ike iduga ọnwụ na oké njọ.Dị ka onye dị iche iche nke kwekọrọ ekwekọ ọgwụ metabolism, ọ na-kewara n'ime anọ phenotypes, ya bụ ultra-fast metabolism (UM, * 17/*17, * 1/*17), ngwa ngwa metabolism (RM, * 1/*1). ) , Metabolism nke etiti (IM, *1/*2, *1/*3), ngwa ngwa metabolism (PM, *2/*2, *2/*3, *3/*3).