Methylated mmadụ NDRG4/SEPT9/SFRP2/BMP3/SDC2 Gene

N'ime ndị okenye, ihe karịrị 10 8 intestinal cell epithelial na-adapụ na mgbidi eriri afọ kwa ụbọchị, a na-esikwa na nsị na nsị site na nnukwu peristalsis bowel.N'ihi mkpụrụ ndụ tumor nwere ike ịdaba na eriri afọ nke mmụba na-adịghị mma, stool nke ndị na-arịa ọrịa eriri afọ nwere ọtụtụ mkpụrụ ndụ na-arịa ọrịa na akụkụ sel ndị na-adịghị mma, nke bụ ihe ndabere maka nchọpụta stool kwụsiri ike.Nnyocha achọpụtala na methylation modification nke ndị na-akwalite mkpụrụ ndụ ihe nketa bụ ihe mbụ mere na tumorigenesis, na ihe mkpụrụ ndụ ihe nketa enwetara site na ihe nlele stool nke ndị ọrịa cancer colorectal nwere ike igosipụta ọnụnọ ọrịa kansa na eriri afọ mbụ.

NDRG4, nke a makwaara dị ka SMAP-8 na BDM1, bụ otu n'ime mmadụ anọ nke ezinụlọ NDRG gene (NDRG1-4), nke egosiri na ọ na-ejikọta ya na mmụba cell, ọdịiche, mmepe na nrụgide.Achọpụtara ya na NDRG4 methylation bụ ihe nwere ike ime biomarker maka nchọpụta na-adịghị emerụ ahụ nke ọrịa cancer colorectal na nlele stool.

SEPT9 bụ onye otu ezinụlọ Septin, nke nwere ma ọ dịkarịa ala mkpụrụ ndụ ihe nketa iri na atọ na-edekọ ngalaba GTPase echekwara nke nwere ike jikọta protein ndị metụtara cytoskeleton, yana njikọ ya na nkewa cell na tumorigenesis.Nnyocha achọpụtala na mkpụrụ ndụ ihe nketa methylated Septin9 na-abawanye nke ọma na nlele stool sitere na ndị ọrịa nwere ọrịa cancer colorectal.

Protein ndị metụtara frizzled (sFRPs) zoro ezo bụ protein soluble bụ klaasị nke ndị na-emegide ụzọ Wnt n'ihi ụkpụrụ ha dị elu maka onye na-anabata frizzled (Fz) maka akara Wnt.Mwepu nke mkpụrụ ndụ ihe nketa SFRP na-ebute mmalite na-achịkwaghị achịkwa nke akara Wnt jikọtara ya na ọrịa cancer colorectal.Ugbu a, enwere ike iji SFRP2 methylation na stool dị ka ihe na-adịghị emerụ ahụ maka nchọpụta nke ọrịa cancer colorectal.

BMP3 bụ onye otu TGF-B superfamily ma si otú a na-arụ ọrụ dị mkpa na mmepe embrayo site n'ịkwalite na ịkpụzi ọkpụkpụ n'oge.BMP3 bụ hypermethylated na cancer colorectal na enwere ike iji ya mee ihe dị mkpa akara akpụ.

SDC2 bụ cell elu heparan sulfate proteoglycan na-etinye aka na nhazi nke ọtụtụ usoro physiological na pathological.A na-edozi anụ ahụ na-agụnye mmụba cell, dị iche iche, adhesion, nzukọ cytoskeletal, mbugharị, ọgwụgwọ ọnya, nkwurịta okwu cell-matrix, angiogenesis;Usoro pathological gụnyere mbufụt na ọrịa kansa.Ọkwa methylation nke mkpụrụ ndụ ihe nketa SDC2 na anụ ahụ cancer colorectal dị elu nke ukwuu karịa nke anụ ahụ nkịtị.